I always try to leave Rincon before 4am, and usually 3am is best. The route I take is the 15 north to the 91 west and then the 5 north to the 10 west. I live in West LA.

If you reach the junction of the 15 and the 91 anytime after 4:30am you will have a ten to fifteen minute wait just to get on the 91, and then traffic will be snarled all the way to LA with early commuters.

On my last trip, I left Rincon at 3am and was home at about 5am with no delays and travel at the speed limit non stop.