Nope, they make no difference. Your play from the point you stop is no different than your play when you return. No magic happens. You are just as likely to win or lose when you return as you were if you had stayed.
No one is saying people should play hours and hours. All that is being said is any reason to quit is good when playing a negative machine. The stop watch method works just as well. Or, you would flip a coin each time you get a quad. It doesn't matter. You keep trying to make this an either or situation. Stop or play forever hours and hours. That is nonsense.