In 10-15 years, the new 'hot' part of the strip should be the north end between spring mountain/sand (fashion show mall) and the sahara. That has been the plan for a while and it is slow in developing. With several projects underway and the convention center expansion should get the ball rolling. They HAVE to take down that big blue monstrosity of a failure, and MGM at some point will need to put Circus Circus to sleep and built something new and modern on that site.
Once the northern strip is developed, complete with safe pedestrian walkways and overpasses, the next part of the strip that I think will see transformation, is Mid-strip, the east side, between Flamingo Road and Venetian/Pallaza. All those years neglected evil empire properties, Consisting of Cromwell, Flamingo, Linq, Harrah's and Casino Royale will go, in favor of some big new project, either financed by the empire if they ever pull themselves from bankcrupcy and start spending, or perhaps someone else, if the empire is forced to sell off some properties. There is the argument that the Linq was recently "redone", but it was sort of a "Lipstick on a pig" type deal rather than a complete renovation.
New moguls? Obviously Wynn and Adelson will be gone. I don't know that you will see the likes of those kind of personalities again. More likely faceless corporations.
I don't think the non-gaming trend will continue...especially the high end retail stuff. Too many high end retail shops on the strip now and Shopping really isn't what the strip and Vegas are about. When you think Vegas, you shouldn't think high end retail. That is not what is going to make Vegas "special". I think they will get away from that. Night clubs and higher end restaurants will probably remain, but I think we will see some emphasis come back to gaming. In the end, that is what Vegas is about!
Gaming: More bells and whistles and lower payouts on machines. Fewer of the traditional table games (BJ, Craps, Roulette) in favor of more specialty games with higher house edge. Of the traditional games that remain, the lower limit games with be replaced by electronic video versions. Only higher limit BJ, Craps and Roulette will be live dealers, except for the iconic places downtown. They will continue to offer lower limit live table games, pretty much as they do now. Downtown is slow to change. The draw of downtown is it's iconicness. (<-lol)
At some point they have to extend the monorail to both the airport and downtown, so it is actually useful. The Deuce has outlive any "charm" that it ever had. The only reason that the monorail didn't connect downtown to airport when it was built was strong resistance from the Taxi, and limo and shuttle van industry. But I don't think that industry has the "pull" they used to. They couldn't stop uber/lyft from coming in.