I predict:

Prostitution in both Las Vegas and Clark county will wane as many casinos will offer patrons the use of a robotic sex doll.

Sex will become even more front and center; Las Vegas will be an anything goes hook up locale, with wild, bacchanalian events throughout the town.

Somebody somewhere will come up with a new casino game that will be incredibly popular.

The Las Vegas Raiders will prove to be a huge hit, with both a strong local fan base and surprisingly strong attendance by fans of their opponents who travel to Sin City to catch their team play the Raiders.

Lake Mead will dry up, causing massive water shortages.