I'll tell you one thing that DOES get to me in Vegas, besides the smoking in the casinos which I detest - there is something in the sheets that after staying long enough, irritates my skin. Not to the point of rash, but just gets itchy. This happens after staying more than a week or so. This trip I've requested hypoallergenic sheets and towels in each room we have been in, and that seems to help. I guess they just use harsh detergents or bleaches on their normal sheets.